Regenerative Medicine

Regenerative Medicine 2018-01-24T22:41:30+00:00

Mayo Clinic:

“Regenerative medicine is a game-changing area of medicine with the potential to fully heal damaged tissues and organs, offering solutions and hope for people who have conditions that today are beyond repair. … [A]dvances in developmental and cell biology, immunology, and other fields have unlocked new opportunities to refine existing regenerative therapies and develop new ones.”

“Regenerative medicine is the process of creating living, functional tissues to repair or replace tissue of organ function lost due to age, disease, damage, or congenital defects.  This field holds the promise of regenerating damaged tissues and organs in the body by stimulating previously irreparable organs to heal themselves.”

National Institutes of Health:

REGENERATIVE MEDICINE

Regenerative Medicine is the exciting and ever dynamic branch of medicine with the purpose of replacing, repairing, renewing or engineering human cells, tissues, organs or their building blocks, utilizing the body’s innate cellular pathways for the purposes of restoring function and homeostasis in the body.  Regenerative cellular Biomedical therapies are powerful adjuncts to the natural healing mechanisms of the human body.

For peak performance these therapies can enhance the quality of life by preventing permanent degeneration and improving treatment outcomes.  The premise of Regenerative Medicine is that tissue degeneration and accompanying pain, inflammation and dysfunction, is a condition or state of “disease” rather than a natural progression of an active life and maximum human longevity potential.

The goals of Regenerative Therapies are to reduce, relieve, or manage painful and certain chronic disease or dysfunctional conditions and improve function, thus increasing the patient’s overall quality of life through minimally invasive Regenerative Medicine procedures.
The implementation of Regenerative Medicine shifts the paradigm of treatment into a focus on healing rather than a focus on pain and dis-ease. It utilizes biomedical substances that provide potential to heal injuries and damaged or degenerated and inflamed tissues by providing bioactive molecules, stem cell building blocks and growth factors that cause and accelerate the body’s natural healing processes.

This exciting cutting-edge “medicine of the future” holds the hope & the promise of efficacy which revolves around the ability of homologous tissue products and cellular products that stimulate stem cells to duplicate themselves or differentiate into specialized cells such as bone, muscle, nerve or other cells and heal damaged or diseased tissue and potentially cure degenerative diseases.

TRANSLATIONAL APPROACH

Regenerative & Anti-Aging Medicine is based upon advanced technological biomedical research and empiricism and offers potential solutions for the prevention, detection and treatment of the cellular breakdown of the human body associated with aging in effort to delay and reverse aging and degeneration and improve outcomes.  

The goal of both Regenerative and Anti-Aging Medicine is to optimize both longevity and to enhance the quality of life.  It is based on the premise that aging and degeneration, in the traditional sense, is a condition or state of “disease” rather than a natural progression of human longevity potential.

Advanced Regenerative Medicine is developed through Translational Medicine, the discipline in biomedical research in which novel discoveries reveal new tools of diagnosis and treatment to improve human health and longevity.

Advanced Regenerative Medicine is a combination of advanced biomedical research and clinical empiricism. Tissue Engineering with natural human products including Advanced Regenerative Medicine has become among the safest & most efficacious methods in Regenerative Medicine. It’s applications include use as a treatment for pain syndromes, diseases and dysfunction arising from varying causes, as an alternative and on occasion, as an adjunct to drugs and surgery.

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THE INHERENT & ORGANIC TISSUE ENGINEERING & REPAIR OCCURRING WITH the NATURAL PROGRESSION of the ACTION of HUMAN PLACENTAL PRODUCT SOURCES HAS BECOME AMONG THE SAFEST & MOST EFFICACIOUS METHODS IN REGENERATIVE MEDICINE.

RELATIONSHIP OF TISSUE ENGINEERING & ADVANCED REGENERATIVE MEDICINE

Our bodies use stem cells to repair themselves, however, our own stem cells are often inhibited by injury, disease, metabolic dysfunction or the aging process. Regenerative therapies employing cell-based therapies, are often synonymous with Advanced Regenerative Medicine or Tissue Engineering. These therapies all provide potential successful treatment for the cellular breakdown caused by inflammation and tissue breakdown resulting in pain syndromes, as well as certain systemic conditions and overall disease and dysfunction.  The differences and interrelationships of these biotechnologies are just now being defined and regulated by FDA Guidelines.

 The most commonly used & most efficacious type of Stem Cell is the Mesenchymal Stem Cell (MSC). Stem cells are undifferentiated basic building blocks of life. They are found in the body’s tissues, organs, and systems. They are able to regenerate into additional stem cells or differentiate into specialized cells, such as bone, muscle, nerve or blood cells. This remarkable ability of adult Mesenchymal Stem Cells (MSCs) makes them irreplaceable in medical treatments.

When (MSCs) or related factors such as exosomes, etc, are injected into a patient’s body, stem cells are signaled and initiate repair, or replace damaged or degenerating tissue.  This takes place through cell-to-cell communication with the surrounding cells thus causing a cellular cascade of healing (paracrine signaling). The term Mesenchymal Stem Cell was coined in the late 80’s by the biomedical research authority, Dr Arnold Caplan of Case Western Reserve. He is considered the father of the MSC & Advanced Regenerative Medicine as we know it. Caplan has now transformed the MSC acronym to “Medicinal Signaling Cell” since these cells secrete powerful bioactive molecules. He now describes them as “a multi-drug site-regulatory dispensary” (Natural Drug Store).

Advanced Regenerative Medicine has been used for decades.  For example, bone marrow transplants for the treatment of blood-related diseases.

Bone marrow is one source of hematopoietic stem cells (HSCs) which are semi-specialized cells that can give rise to new blood cells of all types. MSCs, not provided in significant quantity by bone marrow, are needed to give rise to non-blood tissue types such as cartilage, bone, muscle, and others. MSCs have been shown to be promising in many regenerative therapies but must be obtained from a source other than blood or bone marrow. Another potential drawback of bone marrow transplants is that they involve an invasive surgical procedure.

There are now more than 5000 clinical studies on stem cells in the United States which can be found on www.clinicaltrials.gov. There are also greater than 200,000 peer reviewed scientific publications on pubmed. This rapidly accelerating progress and research indicates the promise of Advanced Regenerative Medicine and other Cellular Biotechnological Therapies.  

In 1978, stem cells were discovered in human umbilical cord blood.  Stem cells are obtained from umbilical cord blood following the birth of live, healthy birthed babies.  While most of these cells are HSCs (Hematopoietic), a small portion are MSCs.  Wharton’s Jelly is within the umbilical cord tissue lining and is a superior and particularly rich sources of MSCs.

The medical information on this website is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment.